Sydnexis Wins Poster Session at Vision by Design 2025: Effect of pH and BAK on Pupil Dilation Following Low-dose Atropine Administration in Dutch Belted Rabbits

We’re proud to share that Sydnexis was named the poster session winner at Vision by Design 2025, the annual conference hosted by the American Academy of Orthokeratology and Myopia Control (AAOMC). This event brings together clinicians, researchers, and industry leaders dedicated to advancing the science and practice of myopia management.

Nick Ruth, Chief Commercial Officer at Sydnexis, presents the award-winning poster during Vision by Design 2025.

Our poster presents findings from a preclinical study evaluating how formulation factors—specifically pH and the preservative benzalkonium chloride (BAK)—affect the pharmacologic response to low-dose atropine. Results showed that a neutral pH formulation containing BAK produced greater and more sustained pupil dilation compared to an acidified, BAK-free formulation, suggesting that these variables can significantly influence drug bioavailability and efficacy in low-dose atropine therapies

You can view the full poster, “Effect of pH and BAK on Pupil Dilation Following Low-dose Atropine Administration in Dutch Belted Rabbits,” below.


VIEW AND DOWNLOAD POSTER HERE

AAOMC-Poster_Pupillometry-Rabbit-Study_Final